Sunscreens, suntans, and skin cancer

Sunscreens in melanoma and skin cancer prevention.

Targeting mutant p53 shows promise for sunscreens and skin cancer.

Chronic exposure to UV light is a risk factor for skin cancer in which signature mutations in the p53 tumor suppressor gene occur due to DNA damage and contribute to cancer development. In this issue of the JCI, Tang et al. report on their study of a nonimmunodeficient mouse model of UVB-induced skin cancer and human skin carcinoma cells and show that the mutant p53 conformation-modifying drug ...

Sunscreens do protect against melanoma, says skin cancer specialist.

Sunscreen can help reduce the risk of malignant melanoma, contrary to the finding of a study that received considerable media attention last February, says a skin cancer specialist at Ohio State University’s Arthur G. James Cancer Hospital and Research Institute. "If you’ve heard or read comments to the effect that sunscreens do not protect against malignant melanoma, forget them," said Ronald ...

Sunscreens, skin photobiology, and skin cancer: the need for UVA protection and evaluation of efficacy.

Sunscreens are ultraviolet radiation (UVR)-absorbing chemicals that attenuate the amount and nature of UVR reaching viable cells in the skin. They are selected and tested for their ability to prevent erythema. No sunscreen prevents photodamage, as it has been demonstrated that suberythemal doses of UVR cause a variety of molecular changes (including DNA damage) in these cells. Furthermore, the ...

Botanicals as sunscreens: Their role in the prevention of photoaging and skin cancer

Botanicals are gaining importance in recent times as active ingredients for cosmetic formulations due to their dermal protective effect against the harmful substances from endogenous and exogenous sources. The probability of exposure of the skin to UV radiation and other environmental factors are more since it is present in the outer layer of body as the primary defense mechanism. The exposure ...